Does early postoperative enteral ecoimmunonutrition enhance intestinal function in gastric cancer?

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Author : Rui Xu, Shuomeng Xiao, Zhi Ding, Ping Zhao
Keyword : gastric cancer, ecoimmunonutrition, enteral nutrition, early nutrition support, surgery
DOI : 10.6133/apjcn.202009_29(3).0004
Issue : Asia Pac J Clin Nutr 2020;29(3):469-475
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Abstract

Background and Objectives: We assessed the effect of enteral ecoimmunonutrition (enteral nutrition involving probiotics and immune nutrients) on gastric cancer in the postoperative period. Methods and Study Design: In total, 60 patients with gastric cancer were randomized into an enteral ecoimmunonutrition group or an enteral nu- trition group. Information on postoperative complications; hospitalization length; time to first bowel movement and first flatus; and differences between preoperative and postoperative nutritional status, inflammatory reactions, and immune function was collected. Results: No significant between-group differences in nutritional status and complications were observed. C-reactive protein concentrations were lower in the enteral ecoimmunonutrition group than in the enteral nutrition group on postoperative day 7 (p<0.001) and CD4+ concentrations were signifi- cantly higher (p=0.01). The enteral ecoimmunonutrition group had a significantly shorter time to first flatus than the enteral nutrition group (p=0.03). Conclusions: Early postoperative enteral ecoimmunonutrition significantly improved immune function, reduced inflammatory responses, and promoted intestinal function recovery in pa- tients with gastric cancer undergoing gastrectomy.

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