Background and Objectives: Hibiscus sabdariffa L. (HS) and Gynostemma pentaphyllum Makino (GP) have been used as traditional medicines to treat diabetes and hypercholesterolemia. Nevertheless, there is inter- individual variation in the metabolic responses to HS and GP consumption. This may be due to genetic factors. The aim of this study was to investigate the effects of HS and GP tea consumption on anthropometric data, fast- ing blood glucose (FBG), and lipid concentrations in hypercholesterolemia subjects with different genotypes of the APOE and CETP TaqIB polymorphisms. Methods and Study Design: Forty-eight subjects with hypercholes- terolemia were given either HS or GP tea for 30 days. Anthropometric and biochemical variables were deter- mined, and APOE and CETP TaqIB polymorphisms were analyzed using the polymerase chain reaction– restriction fragment length polymorphism (PCR-RFLP). Results: E4 (p=0.008) and homozygous B1B1 (p=0.010) carriers had significantly decreased HDL-C concentrations after HS consumption; in addition, B2 carriers who consumed HS showed significantly decreased triglyceride (TG) concentrations (p=0.039). Regarding GP con- sumption, non-E4 carriers had significantly decreased HDL-C (p=0.009) and FBG (p=0.042) concentrations. Fur- thermore, B2 carriers had significantly decreased total cholesterol (TC) (p=0.045), HDL-C (p=0.004), and FBG (p=0.026) concentrations. Conclusions: HS consumption may have beneficial effects with respect to TG concen- trations in the B2 carriers, but it may adversely affect HDL-C concentrations in homozygous B1B1 and E4 carri- ers. In contrast, GP consumption may have favorable effects on TC and FBG concentrations but not on HDL-C concentrations for B2 and/or non-E4 carriers.