Asia
Pacific Journal of Clinical Nutrition
Volume 14, issue 1
(March 2005)
Full
Papers
Contents |
Abstract |
Paper |
Asia
Pacific Clinical Nutrition Society (APCNS) Award -
Susan Parkinson
Asia
Pac J Clin Nutr. 2005;14(1):1.
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Original
Articles |
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Does
diet matter for survival in long-lived cultures?
MARK L WAHLQVIST, IRENE DARMADI-BLACKBERRY, ANTIGONE KOURIS-BLAZOS,
DAMIEN JOLLEY, BERTIL STEEN, WIDJAJA LUKITO AND YOSHIMITSU HORIE
Asia
Pac J Clin Nutr. 2005;14(1):2-6.
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Food
and nutrient intakes among nomads living in three different areas
of Inner Mongolia, China
YOSHIMI OHNO, KAZUKO HIRAI, SANAE SOWA, SACHIKO OKA AND YOKO MURAI
Asia
Pac J Clin Nutr. 2005;14(1):7-18.
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Physical
status, nutrient intake and dietary pattern of adolescent female
factory workers in urban Bangladesh
MOUDUDUR RAHMAN KHAN AND FARUK AHMED
Asia
Pac J Clin Nutr. 2005;14(1):19-26.
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Iodine
status in pregnant women living in Melbourne differs by ethnic
group
MICHELLE A HAMROSI, EUAN M WALLACE AND MALCOLM D RILEY
Asia
Pac J Clin Nutr. 2005;14(1):27-31.
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The
effects of iodine on intelligence in children: a meta-analysis
of studies conducted in China
MING QIAN, DONG WANG, WILLIAM E WATKINS, VAL GEBSKI, YU QIN YAN,
MU LI AND ZU PEI CHEN
Asia
Pac J Clin Nutr. 2005;14(1):32-42.
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pdf |
The
effect of vitamin A-fortified coconut cooking oil on the serum
retinol concentration of Filipino children 4-7 years old
LUZ V CANDELARIA, CLARITA R MAGSADIA, ROWENA E VELASCO, MA REGINA
A PEDRO, CORAZON VC BARBA AND CELESTE C TANCHOCO
Asia
Pac J Clin Nutr. 2005;14(1):43-53.
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pdf |
Correlates of under- and over-reporting of energy intake in Tehranians: body mass index and lifestyle-related factors
FEREIDOUN AZIZI, AHMAD ESMAILLZADEH AND PARVIN MIRMIRAN
Asia
Pac J Clin Nutr. 2005;14(1):54-59.
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pdf |
Waist
girth normalized to body build in obesity assessment
GRETE HEINZ , GARY TC KO AND LOUIS J PETERSON
Asia
Pac J Clin Nutr. 2005;14(1):60-68.
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html |
pdf |
Increased
abdominal fat in young women of Indian origin
BRANDON ORR-WALKER, MARGARET C EVANS, IAN R REID AND TIM CUNDY
Asia
Pac J Clin Nutr. 2005;14(1):69-73.
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html |
pdf |
Anthropometric indices as screening tools for cardiovascular risk
factors in Singaporean women
YONG-HAO PUA AND PECK-HOON ONG
Asia
Pac J Clin Nutr. 2005;14(1):74-79. |
html |
pdf |
Anthropometric
characteristics and nutritional status based on body mass index
of adult Bathudis: a tribal population of Keonjhar District, Orissa,
India. KAUSHIK
BOSE AND FALGUNI CHAKRABORTY
Asia
Pac J Clin Nutr. 2005;14(1):80-82. |
html |
pdf |
Use
of [14C]-sodium bicarbonate/urea to measure physical activity
induced increases in total energy expenditure in free-living healthy
males
DARREN M ROFFEY, NATALIE D LUSCOMBE, NUALA M BYRNE, ANDREW P HILLS,
MAX BELLON, CHRIS TSOPELAS, IAN D KIRKWOOD AND GARY A WITTERT
Asia
Pac J Clin Nutr. 2005;14(1):83-90.
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html |
pdf |
Australian
sweet lupin flour addition reduces the glycaemic index of a white
bread breakfast without affecting palatability in healthy human
volunteers
RAMON S HALL, SARAH J THOMAS AND STUART K JOHNS
Asia
Pac J Clin Nutr. 2005;14(1):91-97. |
html |
pdf |
Clinical
evidence of growth hormone, glutamine and a modified diet for
short bowel syndrome: meta-analysis of clinical trials
YONG ZHOU, XIAO-TING WU, GANG YANG, WEN ZHUANG AND MAO-LING WEI
Asia
Pac J Clin Nutr. 2005;14(1):98-102.
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Protective
effects of bovine colostrum on non-steroidal anti-inflammatory
drug induced intestinal damage in rats
JEONG WOOK KIM, WOO KYU JEON, JUNG WON YUN, DONG
IL PARK, YONG KYUN CHO, IN KYUNG SUNG, CHUNG IL SOHN, BYUNG IK
KIM, JOON SUP YEOM, HYO SOON PARK, EUN JEONG KIM AND MYONG SUK
SHIN
Asia
Pac J Clin Nutr. 2005;14(1):103-107.
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Asian
workshop on "Iron fortification of foods"
RODOLFO F FLORENTINO
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Book
review by MARK WAHLQVIST - "Towards the Global Elimination
of Brain Damage Due to Iodine Deficiency" Senior
editor BASIL HETZEL
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top
Does
diet matter for survival in long-lived cultures?
MARK L WAHLQVIST, IRENE DARMADI-BLACKBERRY, ANTIGONE KOURIS-BLAZOS,
DAMIEN JOLLEY, BERTIL STEEN, WIDJAJA LUKITO AND YOSHIMITSU HORIE
In
1987, the International Union of Nutritional Sciences (IUNS) subcommittee
on Nutrition and Ageing, in conjunction with the World Health Organization
(WHO) global program for the elderly, embarked on the 'Food Habits
in Later Life' (FHILL): a cross-cultural study to determine to what
extent health, social and lifestyle variables, especially food intake,
collectively predict survival amongst long-lived cultures. A total
of 818 participants aged 70 years and over, were recruited from five
IUNS centres. Mortality data were collected after five to seven years.
The cohorts included Swedes in Sweden (SWD), Greeks in Greece (GRS)
and in Melbourne, Australia (GRM), Anglo-Celts in Australia (ACS)
and Japanese in Japan (JPN). Information was obtained on health, lifestyle
and diet at baseline. A Cox Proportional Hazard model containing ten
potential predictors of survival, adjusted to age at enrolment and
ethnicity/locality, was developed to analyse the survival data. Based
on up to seven years survival data, it was found that being an elderly
Greek in Australia conferred the lowest mortality risk and being an
elderly Greek in Greece conferred the highest mortality risk. When
the ten potential predictors of survival were entered into the Cox
model, the memory score, the Mediterranean diet score, Activities
of Daily Living (ADL) and general health status scores showed the
greatest effects in significantly reducing mortality hazard ratios
by 22%, 13%, 4% and 4%, respectively. For diet score, a one-unit change
predicted a significant 13% difference in survival. Of the lifestyle
(modifiable) variables entered in the multivariate model, exercise
and social activity were not significant predictors of survival suggesting
that diet is a more important predictor of survival than these variables.
Another lifestyle variable, smoking, significantly increased mortality
hazard ratios by 67%, making it a more important predictor of survival
than diet. Being male (non-modifiable) also increased risk of death
by 63%. Diet, particularly the Mediterranean Diet, operates irrespective
and together with other factors as an appreciable contributor to survival,
with a strength comparable to or greater than all other measured variables.
The independence and strength of the predictiveness of food pattern
for survival, and for this to be cross-cultural from Europe to Asia
is a novel and important observation for food and health policy.
Key
Words: elderly, Mediterranean diet, culture, survival, longevity,
social factors, exercise, ADL, memory, smoking, gender, FHILL, Greeks,
Swedes, Japanese, Anglo-Celts, Australians.
top
Food
and nutrient intakes among nomads living in three different areas
of Inner Mongolia, China
YOSHIMI
OHNO, KAZUKO HIRAI, SANAE SOWA, SACHIKO OKA AND YOKO MURAI
The subjects, from Mongolian-style gel tribes, aged 6-79 years, living
in three different areas of Inner Mongolia, were asked about their
daily food consumption in August 2001 using the 24-hr dietary recall
method. There were no significant differences in food intakes between
males and females of the same age group in the same area, with a few
exceptions, although considerable variation was found among individuals
and areas for the amount of foods consumed. Some subjects consumed
greater amounts of wheat, vegetables, fruits, and vegetable oils,
which suggested they had changed their eating patterns. All subjects
drank large quantities of tea, to which was added milk (sheep/goat),
cream, butter, parched millet and/or sawa. This traditional tea supplied
vitamins and minerals such as vitamin A, iron and calcium.
Key
Words: nomads, gels, food consumption, tea, milk (sheep/goat),
nutrient intake, traditional food habits, children, adults, elderly,
Inner Mongolia, China
top
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Physical
status, nutrient intake and dietary pattern of adolescent female factory
workers in urban Bangladesh
MOUDUDUR
RAHMAN KHAN AND FARUK AHMED
This
cross-sectional study examined the physical status, nutrient intake
and dietary pattern of adolescent female factory workers in urban
Bangladesh. A total of 1211 postmenarchial girls aged 14-19y from
seventeen readymade garment industries spread over the Dhaka City
participated in the study. Body weight, height and skin fold thickness
were measured for all subjects. The nutrient intake was assessed by
24-h recall method and 7-day food frequency questionnaire was used
to investigate their dietary pattern on a sub-sample of 509 girls.
Sixty five percent of the girls were short (height-for-age, <3rd
percentile of NCHS reference values). Pre-valence of short stature
was higher in the older girls. Mean body weight was 38kg for the 14
year old girls, which gradually increased across the age groups to
about 42 kg for the 18 and 19 year olds. About 17% of the girls were
thin (BMI-for-age <5th percentile of NCHS reference values). Over
all, about 23% were lean (TSFT-for-age<5th percentile of NCHS reference
values). Food intake data revealed a deficit of 1.62 MJ/day in energy.
Mean intake of protein, calcium, iron, vitamin A, thiamin, riboflavin,
niacin and vitamin C were below the recommended dietary allowance.
Most of the energy and nutrients came from cereal grains. Habitual
pattern of food intake revealed poor intake of eggs, milk, meat, and
green leafy vegetables. In conclusion, the data show a poor physical
status of the adolescent female factory workers in Bangladesh. Simultaneous
substantial deficits in energy and several nutrients in their diet
stress the need for an appropriate intervention to improve their overall
nutritional and physical status of these young females..
Key
Words:adolescent girls, stunting, dietary pattern, factory workers,
body size, Bangladesh.
top
Iodine
status in pregnant women living in Melbourne differs by ethnic group
MICHELLE
A HAMROSI, EUAN M WALLACE AND MALCOLM D RILEY
The iodine status of pregnant women from different ethnic groups in
an Australian population was determined by measuring urinary iodine
concentration (UIC) from stored spot urine samples. Study subjects
were selected from pregnant women participating in a Down Syndrome
screening study at Monash Medical Centre in Melbourne, Australia.
In total, 263 Vietnamese, 262 Indian/Sri Lankan (ISL) and 277 Caucasian
women were included. The median UIC of Caucasian women (52 µg/L)
was significantly lower than that of both Vietnamese women (58 µg/L,
P <0.01) and ISL women (61 µg/L, P = 0.03). The proportion
of women who had a UIC below 50µg/L was 48.4% of the Caucasian
women, 38.4% of the Vietnamese women and 40.8% of the ISL women. These
data are consistent with mild iodine deficiency for each of the groups
of pregnant women. The evidence for mild iodine deficiency in these
groups of pregnant women is consistent with recent Australian studies
in pregnant and non-pregnant individuals. The association of ethnicity
with iodine status is most likely due to differences in dietary behaviours.
Understanding the factors that influence iodine nutrition in a multiethnic
population will be important for identifying the most useful approaches
to improving iodine status, evaluating different strategies and the
development of appropriate monitoring programs. Action to improve
iodine status in the Australian population should include consideration
of ethnic differences in diet.
Key
Words: iodine
nutrition, pregnancy, public health, Australia, Vietnamese, Indian,
Sri Lankan, Caucasian women
top
The
effects of iodine on intelligence in children: a meta-analysis of
studies conducted in China
MING
QIAN, DONG WANG, WILLIAM E WATKINS, VAL GEBSKI, YU QIN YAN, MU LI
AND ZU PEI CHEN
This study quantifies the effects of iodine on the intellectual development
of children using a systematic manual literature search of Chinese
publications related to iodine deficiency disorders. The Chinese Medical
Reference Database, Medline, and Cochrane library were searched electronically
in Chinese and English. Inclusion criteria included: studies conducted
in China, comparing children (<16 ys) living in naturally iodine
sufficient (IS) with those in severely iodine deficient (ID) areas,
or children in ID areas born before and after the introduction of
iodine supplementation. Intelligent Quotient (IQ) was measured using
Binet or Raven Scales. The iodine sufficient control groups were comparable
socially, economically, and educationally with the study groups. Random
effects models were used in the meta-analysis. Effect size was the
standard deviation IQ point (SIQP), which is equivalent to 15 IQ.
Thirty-seven reported studies, total 12,291 children, were analysed.
The effect size was an increase of 0.83, 0.82, and 0.32 SIQP respectively,
for the children living in IS communities compared with those living
in ID areas with no iodine supplementation, with inadequate iodine
supplementation, or children who had received iodine during their
mothers' pregnancy and after birth. These equal to 12.45, 12.3, 4.8
IQ points. Compared with that of children whose mothers were persistently
exposed to ID, the total effect size of the 21 entries was an increase
of 0.58 SIQP (8.7 IQ points) in the group receiving iodine supplementation
during pregnancy. Furthermore, there was an increase on 1.15 SIQP
of Binet or 0.8 SIQP on Raven Scale (17.25 or 12 IQ points) for children
born more than 3.5 years after iodine supplementation program was
introduced. The level of iodine nutrition plays a crucial role in
the intellectual development of children. The intelligence damage
of children exposed to severe ID was profound, demonstrated by 12.45
IQ points loss and they recovered 8.7 IQ points with iodine supplementation
or IS before and during pregnancy. Iodine supplementation before and
during pregnancy to women living in severe ID areas could prevent
their children from intelligence deficit. This effect becomes evident
in children born 3.5 years after the iodine supplementation program
was introduced.
Key Words: iodine, iodine deficiency disorders, intelligence,
IQ, children, meta-analysis, China.
top
The
effect of vitamin A-fortified coconut cooking oil on the serum retinol
concentration of Filipino children 4-7 years old
LUZ V CANDELARIA, CLARITA R MAGSADIA, ROWENA E VELASCO, MA REGINA
A PEDRO, CORAZON VC BARBA AND CELESTE C TANCHOCO
A
6-month intervention trial was conducted among 542 Filipino children
aged 4 to 7 years to determine the effect of vitamin A-fortified coconut
cooking oil intake on their vitamin A status and to identify factors
that influence this. Children were randomly assigned to the Experimental
group, with vitamin A-fortified cooking oil ration; to Control-1 group
with unfortified cooking oil ration; and to Control-2 group without
cooking oil ration. In all groups, children's serum retinol concentration
improved. Relative change in serum retinol con-centration was significantly
higher among the Experimental group, with one-third of total vitamin
A intake coming from vitamin A-fortified cooking oil intake, than
in the Control groups, with more than half of intake from other vitamin
A-rich foods. Determinants of post-intervention serum retinol concentration
included baseline serum retinol concentration, caregiver's education,
receipt of high-dose vitamin A capsule, interaction between consumption
of vitamin A-fortified cooking oil and of other vitamin A-rich foods,
and between households purchasing cooking oil and food expenditure.
Intake of vitamin A-fortified cooking oil combined with vitamin A-rich
foods was necessary to increase serum retinol concentration. It is
recommended to vi-gorously promote the consumption of vitamin A-fortified
cooking oil together with other vitamin A-rich sources to sustain
the prevention and control of vitamin A deficiency.
Key
Words: vitamin A fortified coconut cooking oil, vitamin A status,
serum retinol concentration, weight for height, Filipino children,
Philippines
topCorrelates of under- and over-reporting of energy intake
in Tehranians: body mass index and lifestyle-related factors
FEREIDOUN AZIZI, AHMAD ESMAILLZADEH AND PARVIN MIRMIRAN
Under- and over-reporting of energy intake are problems in dietary intake assessment. This study was
conducted to assess the correlates of under- and over-reporting of energy intake in Tehranians. Dietary data on
947 participants (415 males and 532 females) of the Tehran Lipid and Glucose Study was collected by trained
interviewers using two 24-hour recalls. Weight and height were measured by digital scale and tape measure
according to standard protocols and recorded to the nearest 100g and 1cm, respectively. Under-, normal- and
over-reporting of energy intake was defined as ratio of energy intake to basal metabolic rate (EI: BMR) <1.35,
1.35 - 2.39 and ≥ 2.4, respectively. Mean ± SD of age was 37.3 ± 14.6 and 32.9 ± 13.6 years for men and
women, respectively. Men had higher EI: BMR than women (1.72 ± 0.44 vs 1.27 ± 0.44, P<0.001). EI and EI:
BMR was highest in the youngest age groups in both sexes. The prevalences of under- and over-reporting were
31% and 5%, respectively. Fewer men than women underreported EI (19% vs 40%, P<0.001). The fraction of
over-reporters was significantly higher in men than women (7% vs 3%, P <0.05). EI: BMR decreased with age.
Under-reporters were older and had higher BMI than normal-reporters, but their educational level did not differ
significantly. Over-reporters were younger and had lower BMI than normal-reporters, but their educational
levels did not differ significantly. Most over-reporters had normal BMI. Smoking was more prevalent in overreporters
than in the normal-reporters (28% vs 19% in men and 6% vs 1% in women, P<0.01). The results
showed a high prevalence of misreporting of energy intake in Tehran. This phenomenon is related to age,
obesity and smoking habits.
Key Words: under-reporting, over-reporting, BMI, lifestyle, Tehran Lipid and Glucose Study, Iran
top
Waist
girth normalized to body build in obesity assessment
GRETE HEINZ , GARY TC KO AND LOUIS J PETERSON
Waist
girth (WG) is regarded as the most significant anthropometric parameter
associated with cardiovascular risk. The objective of the present
study was to strengthen WG as an obesity marker by basing WG assessment
not on gender but on individually measured body build characteristics
that need not coincide with gender. We formulated a new marker, the
Waist Reference Girth (WRG) and two corollaries, the Waist Deviation
(WD) and the Percent Waist Deviation (%WD). The present research centered
on deriving an equation for WRG from relevant trunk skeletal measurements
that closely predicted WG in lean individuals. This equation would
determine any individual's WRG and current WD. Trunk skeletal widths
and chest depth as well as WG were measured on 507 physically active
subjects (247 men and 260 women), predominantly lean young adults.
Multiple regression analysis with the skeletal measurements as independent
variables was performed on this data to predict WG. The unisex WRG
equation WRG = Chest Sum ´ 1.635 predicted WG of 282 lean subjects
(maximum WD of 4 cm) with R2 of 0.87 (SEE of 3.0 cm). Male and female
WG cutoff values for central obesity are usually taken at 94 cm and
80 cm respectively. For the average male and female WRG in this study
(79 cm and 67.4 cm), these cutoff values are equivalent to WD of 15cm
and 12.6cm respectively and to 19%WD for both genders (15/79 and 12.6/67.4).
With %WD normalized for WRG, hence unaffected by intra-group or inter-group
variations in the Chest Sum, %WD thresholds may better identify health
risks linked to abdominal obesity than existing WG thresholds.
Key Words: waist girth, body build, waist reference girth, waist deviation,
abdominal obesity, waist circumference
top
Increased
abdominal fat in young women of Indian origin
BRANDON ORR-WALKER, MARGARET C EVANS, IAN R REID AND TIM CUNDY
People
of Indian origin develop type 2 diabetes at a relatively young age
and low body mass index compared to people of other racial groups,
possibly because of preferential accumulation of abdominal fat. We
examined the relationship between abdominal fat and body mass index
(BMI) in healthy premenopausal women of different racial groups, and
compared abdominal fat measurements at different ages. Women of Chinese,
European, Indian or Polynesian origin (50 of each, mean age 31) had
dual energy x-ray absorptiometry of the lumbar spine, with estimation
of the percentage fat in the abdominal area. Polynesian women had
a significantly greater mean BMI (P<0.001) than all other groups,
and a higher abdominal fat than European and Chinese woman (P<0.001).
Although the Indian women had a similar mean BMI to the European and
Chinese women, they had a significantly greater abdominal fat (P<0.001).
When examined by age tertile, the Indian women had significantly more
abdominal fat than Chinese or European women at all ages (P<0.001),
with marked differences evident even in the youngest group (mean age
23 years). Compared to other racial groups, women of Indian origin
preferentially accumulate abdominal fat - a trait that is well established
in young adulthood.
Key
Words: abdominal obesity, diabetes, body mass index, fat mass, premenopausal
women, Chinese, European, Polynesian, Indian
top
Anthropometric
indices as screening tools for cardiovascular risk factors in Singaporean
women
YONG-HAO
PUA AND PECK-HOON ONG
Previous studies have suggested the need to revise the World Health
Organization (WHO) cut-off values for the various indices of obesity
and fat distribution in Singapore. The purpose of this study was to
delineate cut-off points of body mass index (BMI), waist-hip ratio
(WHR), waist circumference (WC), and waist-stature ratio (WSR) as
screening tools for cardiovascular risk factors in Singaporean women.
Anthropometric indices were measured in a cross sectional survey of
566 subjects (60% Chinese individuals, 28% Malay individuals and 12%
Indian individuals). Cardiovascular risk factors were determined by
measuring blood pressure, serum lipids, and fasting blood glucose
levels. Receiver Operating Characteristic (ROC) curves were constructed
to determine cut-off points. Forward logistic regression and area
under curves (AUC) were used to determine the best anthropometric
index. For at least one cardiovascular risk factor (hypertension,
dyslipidaemia and diabetes mellitus), the cut-off points for BMI,
WHR, WC and WSR were around 23.6kg/m2, 0.80, 77.8cm and 0.48 for Singaporean
females. The AUC of WSR was the highest for all three risk factors
in females (0.79 for hypertension, 0.70 for dyslipidaemia, 0.88 for
diabetes mellitus). Regression analyses revealed that WSR was independently
associated with all risk factors. For Singaporean female adults, the
cut-off points were lower than the criteria suggested by the WHO,
but were in agreement with those reported for Asians. BMI, WHR, WC
and WSR may be used as screening tools for cardiovascular risk factors,
of which WSR may be the best anthropometric index.
Key Words: abdominal
fatness, public health, cut-off values, body mass index, obesity,
waist hip ratio, Singapore.
top
Anthropometric
characteristics and nutritional status based on body mass index of
adult Bathudis: a tribal population of Keonjhar District, Orissa,
India.
KAUSHIK BOSE AND FALGUNI CHAKRABORTY
A cross-sectional study was undertaken to determine anthropometric
profile and nutritional status based on body mass index (BMI) of adult
Bathudis, a tribal population of Orissa, India. A total of 409 adult
(aged > 18 years) Bathudis of three villages of Anandapur, Keonjhar
District, Orissa, India, were studied. Anthropometric measurements
including height, weight, circumferences and skinfolds as well as
BMI and waist-hip ratio (WHR) were measured. Overall, the extent of
undernutrition (BMI < 18.5) was found to be very high (57.9%).
Moreover, there was a significant (c2 = 8.09674, P = 0.01745) difference
in the prevalence of undernutrition between men (52.7%) and women
(64.5%). In conclusion, this study demonstrated that the prevalence
of adult undernutrition was found to be very high among the Bathudis,
a tribal population of Keonjhar District, Orissa. These rates were
much higher than those found in several tribal populations from other
parts of India. Therefore, immediate nutritional intervention programs
are needed for implementation among Bathudis. Moreover, further research
is needed not only among this ethnic group but also other tribal populations
of India to fully understand the causes and consequences of adult
undernutrition.
Key
words: tribal population, anthropometry, body mass index,
nutritional status, Bathudis, West Bengal, India
top
Use
of [14C]-sodium bicarbonate/urea to measure physical activity induced
increases in total energy expenditure in free-living healthy males
DARREN
M ROFFEY, NATALIE D LUSCOMBE, NUALA M BYRNE, ANDREW P HILLS, MAX BELLON,
CHRIS TSOPELAS, IAN D KIRKWOOD AND GARY A WITTERT
The aim of this study was to evaluate the utility of the [14C]-sodium
bicarbonate/urea technique to detect physical activity-induced increases
in total energy expenditure in free-living healthy men. Thirteen healthy
males aged 34.1 ± 11.7 yrs with body mass index 24.1 ±
3.1 kg/m2 were studied on three separate occasions, during which [14C]-bicarbonate
was infused over 48-hours and urine was collected during the second
24-hours. On three separate occasions and in random order, subjects
either remained sedentary, or performed a bout of physical activity
on an electro-magnetically braked cycle ergometer sufficient to increase
energy expenditure by 7% or 11% above predicted sedentary total energy
expenditure. Urine samples were analyzed to evaluate the amount of
[14C]-bicarbonate incorporated into urinary urea, thereby reflecting
the amount of CO2 produced per day, and upon conversion, the number
of kilojoules of energy expended in 24-hours. All 13 subjects successfully
completed the two physical activity treatments and there were no adverse
events. As measured by the [14C]-urea assay, mean total energy expenditure
values were not significantly different between sedentary activity
(17902 ± 905 kJ/day), the physical activity treatment designed
to increase TEE by 7% (17701 ± 594 kJ/day) and the physical
activity treatment designed to increase TEE by 11% (18538 ±
485 kJ/day) (P=0.668). In conclusion, although the [14C]-sodium bicarbonate/urea
technique was well tolerated and did not interfere with normal daily
activities, it was not able to accurately measure physical activity-induced
increases in EE in the range of 7-11% above predicted sedentary total
energy expenditure.
Key
Words: energy expenditure, carbon dioxide production, exercise prescription,
sodium bicarbonate, urea.
top
Australian
sweet lupin flour addition reduces the glycaemic index of a white
bread breakfast without affecting palatability in healthy human volunteers
RAMON
S HALL, SARAH J THOMAS AND STUART K JOHNS
The addition of some legume ingredients to bread has been associated
with effects on glycaemic, insulinaemic and satiety responses that
may be beneficial in controlling type 2 diabetes, cardiovascular disease
and obesity. However, the effect of Australian sweet lupin (Lupinus
angustifolius) flour (ASLF) is unknown. This investigation examined
the effect of adding ASLF to standard white bread on post-meal glycaemic,
insulin-aemic and satiety responses and palatability in healthy subjects.
Using a randomised, single-blind, cross-over design, 11 subjects consumed
one breakfast of ASLF bread and two of standard white bread ³
7 days apart after fasting overnight. Each breakfast also included
margarine, jam, and tea with milk and contained 50g available carbohydrate.
On each test day, blood samples were taken after fasting, then several
times over 2 hours post-prandially, and analysed for plasma glucose
and serum insulin. Subjects rated breakfast palatability and perception
of satiety, in the fasting state and over 3 hours post-prandially,
after which food intake from an ad libitum buffet and for the rest
of the day was recorded. Incremental areas under the curves for glucose,
insulin and satiety, glycaemic index, insulinaemic index and satiety
index were calculated. ASLF addition to the breakfast reduced its
glycaemic index (mean ± SEM; ASLF bread breakfast = 74.0 ±
9.6. Standard white bread breakfast = 100, P=0.022), raised its insulinaemic
index (ASLF bread breakfast = 127.7 ± 12.0. Standard white
bread breakfast = 100, P=0.046), but did not affect palatability,
satiety or food intake. ASLF addition resulted in a palatable breakfast;
however, the potential benefits of the lowered glycaemic index may
be eclipsed by the increased insulinaemic index.
Key Words: lupin, glycaemic index, insulinaemic index, satiety,
palatability, white bread
top
Clinical
evidence of growth hormone, glutamine and a modified diet for short
bowel syndrome: meta-analysis of clinical trials
YONG
ZHOU, XIAO-TING WU, GANG YANG, WEN ZHUANG AND MAO-LING WEI
This study assessed the safety and efficacy of growth hormone (GH)
and glutamine (GLN) combined with a modified (high-carbohydrate-low-fat,
HCLF) diet in patients with short bowel syndrome. A meta-analysis
of all the relevant clinical trials was performed. Clinical trials
were identified from the following electronic databases: MEDLINE,
EMBASE, the Cochrane Controlled Trials Register, Chinese Bio-medicine
Database. The search was undertaken in May 2004. Language was restricted
to Chinese and English. Literature references were checked at the
same time. Clinical trials were extracted and evaluated by two reviewers
independently of each other. The statistical analysis was performed
by RevMan4.2 software which was provided by the Cochrane Collaboration.
A P value of <0.05 was considered statistically significant. Thirteen
trials involving 258 patients were included. The combined results
showed that GH, GLN and HCLF diet had positive treatment effect on
body weight (weighted mean difference [WMD] = 2.44, 95%CI [1.62, 3.27],
P<0.00001), stool output (WMD = -376.49, 95%CI [-600.35, -152.63],
P=0.001), lean body mass (WMD = 2.16, 95%CI [0.91, 3.41], P=0.0007),
absorption of carbohydrates (WMD = 6.21, 95%CI [5.27, 7.15], P<0.00001),
absorption of nitrogen (WMD = 10.83, 95%CI [5.22, 16.44], P=0.0002),
absorption of D-xylose (WMD = 0.37, 95%CI [0.29, 0.44], P<0.00001),
and off TPN (total parenteral nutrition) (odds ratios [OR] = 64.63,
95%CI [15.51, 269.22], P<0.00001). But there were no improvements
in fat mass (WMD = -1.50, 95%CI [-3.48, 0.48], P=0.14), absorption
of energy (WMD = 7.48, 95%CI [-7.22, 22.17], P=0.32), and absorption
of fat (WMD = 7.16, 95%CI [-2.95, 17.28], P=0.17). Most patients had
side effects that are known to occur during treatment with high doses
(0.14 mg/kg/day) of GH. No serious adverse effects occurred during
active treatment with low doses (£0.1 mg/kg/day) of GH. Treatment
with a combination of low-dose GH, GLN and HCLF diet is effective
without any major adverse effects in patients with short bowel syndrome.
Further trials are required, especially in children, with sufficient
size and rigorous design. .
Key
Words: short bowel syndrome, growth hormone, glutamine, high carbohydrate
low fat diet, meta-analysis
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Protective
effects of bovine colostrum on non-steroidal anti-inflammatory drug
induced intestinal damage in rats
JEONG WOOK KIM, WOO KYU JEON, JUNG WON YUN, DONG IL
PARK, YONG KYUN CHO, IN KYUNG SUNG, CHUNG IL SOHN, BYUNG IK KIM, JOON
SUP YEOM, HYO SOON PARK, EUN JEONG KIM AND MYONG SUK SHIN
The aim of this study was to examine whether bovine colostrum was
able to prevent the NSAID induced small intestinal damage in animals.
The animal model population of the study consisted of 4 groups: control
group, diclofenac group, diclofenac with 10% low fat milk group and
diclofenac with 5% colostrum group. The animals with milk or colostrum
were fed with 10% low fat milk or 5% colostral solution for 5 days
before the administration of diclofenac. Gut injuries were induced
by administration of a single dose of diclofenac (100 mg/kg orally).
Epithelial permeability values (24 hour urinary excretion of 51Cr-ethylenediaminetetraacetic
acid [51Cr-EDTA]), enteric aerobic bacterial counts, serum biochemical
profiles and pathologic findings of distal ileum were measured. Diclofenac
caused a marked increase in the intestinal permeability, enteric bacterial
numbers and intestinal villous damage, and enteric protein and albumin
loss. Combined administration of bovine colostrum reduced the increase
in intestinal permeability, enteric bacterial overgrowth, protein
losing enteropathy and mucosal villous damage of the small intestine
induced by diclofenac. Bovine colostrum may have a beneficial effect
in prevention of NSAID induced small intestinal injuries.
Key
Words:anti-inflammatory agents, non-steroidal, adverse effects, small
intestine, intestinal damage, colostrum.
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Last
Updated: March 2005